Data and methods Accepted project proposals PROSTRESS Predict and model development of stress resilience in real life

Author: Erno Hermans
Affiliation(s): Donders Centre for Cognitive Neuroimaging, Radboud university medical centre
Keywords: resilience, stress reactivity, EMA, brain networks, proactive/reactive traits
Research question(s): 

  • Can we validate the operationalization of the resilience construct?
  • Can we replicate and extend predictors of stress resilience?
  • Can we establish affective and physiological reactivity to stress in real life as a new marker of long-term resilience?
  • Can baseline intrinsic connectivity between fronto-amygdala circuits and fronto-striatal circuits differently predicts resilience outcomes


Abstract:
This proposal concerns the first validation steps that are required as as part of Erno Hermans' VICI project PROSTRESS. The PROSTRESS project aims to understand how people build resilience to stressors. The core hypothesis is that stress-related maladaptation results from a mismatch of perceived agency with environmental controllability, and therefore, that stress resilience results from calibration of the balance between proactive and reactive responses to stressors. The key objective is to translate the neurocomputational and neuromodulatory mechanisms involved in decision-making reinforcement of proactive and reactive stress-response strategies into real life. For this translation, HBS data was included in the VICI project proposal. The goals of the initial validation steps that are part of the current HBS analysis project proposal are to establish and validate a measure of stress resilience (the absence of stress-related mental health complaints despite exposure to stressors), within the framework of HBS data, and conduct initial analyses regarding several known resilience factors (factors that are prospectively associated with later stress resilience). These initial validation steps are needed to address the core hypotheses of the PROSTRESS project, which concern changes in resilience as a function of experienced controllability, in a later stage.